Fresh analysis suggests that patients who come off popular GLP-1 drugs like semaglutide or tirzepatide may regain reduced body mass far faster than those who stop conventional diet and exercise regimens.
Research printed in a leading health publication points out that while overweight individuals often shed about a fifth of their total mass while using the jabs, the weight returns at an average rate of 0.8 kg per month once they quit.
"Users purchasing these drugs need to be cognizant of the risk of quick weight regain when the therapy concludes," warns expert Dr. Susan Jebb.
This pace of regain implies a reversion to original mass in about 18 months.
Weighing Treatments
The study, which reviewed 37 of studies involving over 9,000 of participants, contrasted the results of these new drugs with other pills.
Scientists note that people who lose weight through diet and exercise typically experience a less rapid weight regain—approximately 100 grams monthly—after stopping.
The Reason for the Quick Regain
Experts suggest the mode of action of the jabs is key to understanding the accelerated rebound.
These medications imitate a body's own chemical called GLP-1, which moderates appetite.
"Sustained high doses of the hormone levels several times higher than the body's typical production may cause the system to generate a reduced amount of its endogenous hormone, and may also reduce sensitivity to its effects," said Dr. Adam Collins, a dietetics expert.
"Stopping of this hormone supplement means hunger is uncontrolled, making overeating much more probable."
A Chronic Condition?
Health authorities advise the injections for people with obesity-related medical conditions, alongside prescribed lifestyle changes.
A number of clinicians contend that, considering the likelihood of weight regain, the therapy should be considered ongoing.
This view is supported by pharmaceutical companies, who note that the results "highlight the long-term character of excess weight," similar to managing conditions like diabetes.
Patient Experiences
People who have come off the medication describe a intense resurgence of hunger.
"It was like a trigger activating and I was suddenly ravenous," said one woman.
This difficulty is worsened if users have not adopted permanent dietary or behavioural modifications during therapy.
Widespread Adoption
Recent estimates indicate that a significant number of adults in the UK have tried weight-loss jabs in the past year, with interest being substantial.
- Use is higher among women than men.
- The 40s and 50s age group shows the greatest level of interest.
- Many obtain the medications through private healthcare rather than public health services.
In conclusion, researchers caution that while the jabs are effective agents for weight loss, they are not a standalone cure and long-term success relies on combined behavioural changes.
